LRRK2 and Mental deterioration: Here, we extended previous studies on the brain-age gap in PD14-16,18 by determining differential contribution of molecular and behaviour markers of PD and AD pathology to the brain-age gap in PD cases, examining the brain-age gap in asymptomatic and clinical PD cases with GBA and LRRK2 mutations and identifying associations of the brain-age gap with domain specific cognitive decline.