In asymptomatic autosomal dominant AD cases, regional brain volume increases were found associated with neuroinflammation with glial activation and neuronal hypertrophy, which were followed by neurodegeneration and related brain atrophy only in clinical stages of autosomal dominant AD.62 Whether such mechanisms also play a role in asymptomatic LRRK2 cases remains to be investigated in future autopsy studies. Here, LRRK2 is linked to Brain atrophy.