As demonstrated in previous studies, senescent or damaged erythrocytes target splenic macrophages and DCs.[275] Furthermore, high CD47 expression on erythrocytes frustrates the clearance of reticuloendothelial cells and macrophages, leading to prolonged circulation.[128, 276] The characteristic of splenic APC targeting facilitates the application of hybridized cell membrane vaccines developed from tumor membranes and erythrocytes. This evidence concerns the gene CD47 and neoplasm.