Several studies have focused on scrutinizing TEXs from tumor cells transduced with the MHC II transactivator protein CIITA (Class II transactivator) gene.[188, 189] These TEXs vaccines, made from DCs, were observed to upregulate MHC II and CD80 expression, heightening the production of inflammatory cytokines such as TNF‐α, IFN‐γ, and IL‐12. This evidence concerns the gene TNF and neoplasm.