CD8A and neoplasm: After assembling the antigen fragments with the class I MHC α and β2m chains in the endoplasmic reticulum (ER), DCs present peptide‐loaded MHC I complexes on surfaces, activating multiple specific CD8+T cells to annihilate tumor cells, resulting in the stimulated release of tumor antigens and DAMPs, which can be captured by DCs.[33, 34] This tumor killing cascade is constantly augmented until tumor clearance (Figure 1).