SH2D3A and COVID-19: Since great success has been achieved in protecting COVID‐19, many studies are involved in the development of mRNA vaccines, which can be made into two forms: non‐replicating mRNA and self‐amplifying mRNA (saRNA).[287, 288] Conventional mRNA (non‐replicating mRNA) is prepared by in vitro transcription (IVT) or chemical synthesis, loaded via NPs or LNPs.[289] saRNA comprises of a part of alphavirus genome containing nsP1‐4 and RNA sequence coding target molecules.