EIF2AK3 and neoplasm: Anthracyclines have been proven to enhance p53 expression, which activates PERK signaling and EIF2α phosphorylation, leading to ER stress (also termed integrated stress response, ISR), whereas metal‐based chemicals induce ROS, igniting oxidative stress.[223] All of these products can ignite inflammatory pathways and promote neoantigen generation when they are captured by APCs.[224] However, many studies focus on tumor membrane carrying chemotherapeutics for cancer treatment, yet membranes of chemically pre‐incubated tumor cells have not received considerable attention.