NPs with the chemokine C‐C motif ligand 21 (CCL21), ferritin, and melittin, along with lipids, have been reported as APC targeting in LNs, accelerating tumor remission.[277, 278, 279] As carriers of mRNA vaccines, lipid nanoparticles (LNPs) made from 113‐O12B have shown outstanding LN‐targeting specificity and remarkably elevated CD8+ T cell cytotoxicity with OVA‐encoding RNA in a B16F10‐OVA tumor model.[280] All the results above can offer acceptable strategies capable of enhancing tumor membrane vaccines. This evidence concerns the gene CD8A and neoplasm.