SIRPA and cancer: In Li Y. et al.’s inquiry with genetically engineered tumor cells with the anti‐CD40 single chain variable fragment (scFv), the tumor cell membranes in the vaccine abounded with scFvs, accelerating DC maturation and effectively inhibiting MC38 tumor progression in CD40‐humanized mice.[99] Cancer cells can escape from phagocytosis via the connection of CD47 with the signal regulatory protein α (SIRPα, or CD172a) in what is known as a “don't eat me” signal.[100] TCMNPs from some cancer cells are rich in CD47, which helps avoid removal by macrophages, prolonging their half‐lives.[101]