The core of inorganic NPs consists of various inorganic materials, such as gold, iron, silica, carbon, titanium, and manganese, which can stimulate innate immunity via the NLRP3 inflamasome, the cGAS‐STING pathway, and reactive oxygen species (ROS).[58, 59] The organic elements are designed as a shell structure for protecting immune clearance.[60] As natural organic materials, TCMs possess most of the properties of artificial organic structures, in addition to tumor antigen provision and tumor targeting assets, pointing to the synergism between TCMs and inorganic cores in cancer therapies. Here, NLRP3 is linked to neoplasm.