CCL2, also recognized as monocyte chemoattractant protein‐1 (MCP‐1), was initially identified and purified from the culture supernatants of peripheral blood mononuclear cells and tumor cell lines in 1989.[24] Being the first discovered and extensively studied CC family chemokine, CCL2 exhibits a preference for binding to its receptor, CCR2. This evidence concerns the gene CCL2 and neoplasm.