CCL2 and neoplasm: Prior investigations have suggested that the CCL2/CCR2 signaling axis is implicated in various biological processes, including the promotion of pathological angiogenesis, facilitation of the survival and invasion of tumor cells, and the recruitment of immune inhibitory cells.[24] In the peripheral nervous system, a preceding investigation[25] elucidates the involvement of the CCL2/CCR2 axis in the dorsal root ganglia (DRG) concerning neurological pain.