However, among Chinese patients with RA, compared with those without malignancy, patients with malignancy were more male (30.5% vs. 20.9%), had a higher proportion of positive RF (86.4% vs. 69.4%) and positive ACPA (88.1% vs. 69.3%), as well as a higher level of CRP (median 12.1 mg/L vs. 6.4 mg/L), and were more likely to have previous uses of glucocorticoids (61.9% vs. 48.9%) and csDMARDs (83.1% vs. 69.4%), but less uses of bDMARDs (1.7% vs. 7.2%, all P < 0.05). The gene discussed is PRTN3; the disease is rheumatoid arthritis.