BRCA1 and breast cancer: An excellent example of complex requirements for counseling is hereditary breast and ovarian cancer (HBOC): women with a pathogenic germline variant in BRCA (gBRCA) have a significantly increased risk of developing breast and ovarian cancer (OC) compared with the general population,1 with a cumulative breast cancer risk to age 80 of 72% for BRCA1 and 69% for BRCA2, and an OC risk of 44% and 17%, respectively.2