Research has found that fMLF (a mature FPR1 activator) and ANXA1 derived from the supernatant of necrotic tumor cells can activate FPR1 in glioblastoma cell line U87, causing increased intracellular Ca2+mobilization and inducing tumor cell migration, invasion, proliferation, and colony formation 10。The experimental results of Babbin BA et al. This evidence concerns the gene ANXA1 and neoplasm.