showed that AnxA1, Ac2‐26, and other FPR agonists (fMLP and WKYMVm) activate FPR to induce intracellular calcium release in colorectal adenocarcinoma cell line SKCO‐15, leading to an increase in SKCO‐15 invasion 33。Studies have shown that the expression or functional status of FPR is related to drug resistance of tumor cells.18, 34. Here, ANXA1 is linked to colorectal adenocarcinoma.