Reduced levels of BDNF in type 2 diabetes are caused by a combination of chronic hyperglycemia, which leads to oxidative stress and advanced glycation end products (AGEs) formation, insulin resistance that disrupts BDNF signaling, and inflammation from cytokines like TNF-α and IL-6, which inhibits BDNF expression and neurogenesis [3-5]. This evidence concerns the gene BDNF and type 2 diabetes mellitus.