TNF receptor 1 (TNFR1) induces apoptosis and has negative ionotropic effects whereas TNFR2 promotes cell adhesion, angiogenesis, and cell survival, making TNFR1 and TNFR2 agonists potent agents in the management of HF in patients with RA, along with risk factor analysis [29]. This evidence concerns the gene TNFRSF1B and rheumatoid arthritis.