APOH and autoimmune polyendocrinopathy: APS is a systemic autoimmune condition characterized by recurrent vascular thrombosis involving both arteries and veins, fetal losses, and thrombocytopenia in the presence of antiphospholipid antibodies (aPL), including lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL), and anti-β2 glycoprotein-I (anti-β2GPI) [6,7].