Additionally, we highlighted two important proteins in the human proteome without previously known metal-binding annotations from UniProt (Fig. 1h), including the Beclin-1 (UniProt ID: Q14457), which plays a critical role in autophagy, predicted as Zn bound and the ribitol-5-phosphate transferase FKTN (UniProt ID: O75072), which is closely associated with cardiomyopathies, predicted as Mg or Ca bound. Here, FKTN is linked to cardiomyopathy.