For instance, DDX3X (Dead Box Helicase 3, X-Linked), KDM6A/UTX (Lysine Demethylase 6A/UTX), MAGEC3 (Melanoma Antigen Gene Family, Member C3), CNKSR2 (Connector Enhancer of Kinase Suppressor of Ras 2), KDM5C (Lysine Demethylase 5C), ATRX (Alpha Thalassemia/Intellectual Disability Syndrome X-Linked) are tumor suppressor X-linked genes located in the non-pseudoautosomal region (PAR) which has been reported to escape silencing by XCI and thus contribute to cancer sex bias (Dunford et al., 2017). Here, CNKSR2 is linked to alpha thalassemia spectrum.