AT III, a crucial natural anticoagulant protein, plays a significant role in sepsis-related liver injury through several mechanisms: (1) inhibition of coagulation factors (thrombin, factor Xa), thereby preventing microthrombosis formation; (2) suppression of inflammatory factor production (IL-6, TNF-α); (3) maintenance of vascular endothelial cell integrity; (4) promotion of hepatocyte regeneration (26–29). The gene discussed is SERPINC1; the disease is Sepsis.