In this research, we performed a bioinformatics analysis to detect shared molecular mechanism-based biomarkers (CEBPA, TGFBR2, EZH2, JUNB, JUN, FOS, PLAU, COL1A1) between NSCLC and AMI, validating their correlation and identifying candidate drugs targeting hub genes. This evidence concerns the gene JUNB and non-small cell lung carcinoma.