Indeed, in vitro ADCP analyses of human FcR-positive monocytic MonoMac-6 cells, in co-cultures with human CD20+ B-cell lymphoma Granta-519 cells opsonized with different IgG isotypes of RTX, demonstrate that RTX-IgG3 is more effective than RTX-IgG1 in inducing phagocytosis (Figure 1A) (Supplementary Figures S3, S4). This evidence concerns the gene IGHG3 and B-cell non-Hodgkin lymphoma.