STAT3 and neoplasm: On the other hand, it has been recently reported that STAT3 can act as a major transcription factor responsible for the regulation of IL-6 and IL-11 production via PAFR-dependent pathway in tumor cells and cancer-associated fibroblasts (30), suggesting the potential role of STAT3 in the enhanced SaLTA-induced NO production by MDP via PAFR dependent pathway.