PFKFB3 and Sepsis: In the context of sepsis, there is a transition of PFK2 from the less active L-type, which is encoded by the fructose-2,6-bisphosphatase 1 (PFKFB1) gene, to the more potent U-type, encoded by the fructose-2,6-bisphosphatase 3 (PFKFB3) gene.