Despite discrepancies, the majority of CIN1 have clusters with low expression of the tumour markers CDKN2A and KRT7 and higher expression of ARG1. To a certain extent, the opposite is seen in CIN2/3 clusters with high expression of tumour markers and low expression of ARG1. Except for one clear cluster with low expression of HLA-DQB2 in the CIN2/3 group, the expression of HLA-DQB2 does not clearly differentiate between CIN1 and CIN2/3 (see Figure 2). The gene discussed is KRT7; the disease is neoplasm.