AKR1B10 and immune system disorder: Some studies indicated that decreased AKR1B10 expression promote M2 macrophage marker expression in THP1 macrophage cells (46), promote NK cell kill activity on liver cancer cell Huh7 (47), and knock down of AKR1B8 transgenic mice (homologous of AKR1B10 in mice) show a immunity disorder in colon (48), however, the correlation between AKR1B10 expression and immune infiltration in STAD remains elusive.