In this pan-cancer analysis we found that AKR1B10 is increased in GBM, LUAD, LUSC, CHOL, LIHC, PAAD, KIRP, UCEC and CESC, but decreased in STAD, COAD, READ, KICH, BLCA and PRAD. The gene discussed is AKR1B10; the disease is glioblastoma.