In general, AKR1B10 mRNA down-regulated in most of gastrointestinal cancer, genitourinary cancer and PCPG, but up-regulated in most of developmental gastrointestinal cancer, some of gynecological cancer, glioma and lung cancer when compared with normal tissues from TCGA databases (Figure 2A). Here, AKR1B10 is linked to urogenital neoplasm.