Although the single cell RNA-Sequencing revealed AKR1B10 expression was mainly restrained in epithelial cells, we found that AKR1B10 expression was significantly associated with tumor purity, stromal cells, various immune cells infiltration (e.g., neutrophils, dendritic cells and CD4+ T cells) and immune gene expression. The gene discussed is AKR1B10; the disease is neoplasm.