CXCR4 and neoplasm: For example, XPO1+ Epithelial can interact with immune cells via several ligand-receptor pairs, such as MIF-(CD74+CXCR4) and MIF-(CD74+CD44), which, as previously reported, function as recruiters of immunosuppressive cells and thus promote immunosuppression, enabling tumor cells to evade immune surveillance (47, 48, 69).