In present clinical practice, laboratory tests play a central role in evaluating the severity of coagulopathies and the effectiveness of heparin therapy in sepsis, mainly those parameters related to the pathophysiological processes of sepsis-induced coagulation activation, such as prothrombin time (PT), international normalized ration (INR), D-D, FDP and platelet (53). The gene discussed is F2; the disease is Sepsis.