METTL13 and cancer: In recent years, due to two distinct seven-β-strand methyltransferase (MTase) structural domains (MT13-C and MT13-N), METTL13 methylates the N-terminus and Lys55 of eEF1A, respectively, facilitating the synthesis of specific amino acids with high specificity, which contributes to a pro-cancer effect and is ubiquitous in mammalian cells and tissues [6,11,12].