Notably, genes, such as DDX11 (12p11.21), IGLV2-18 (22q11.22), OR8G5 (11q24.2), PARP4 (13q12.12), USP10 (16q24.1), and ZNF208 (19p12), exhibited multiple mutations and demonstrated tumor-driving effects (Figure 8B). Here, PARP4 is linked to neoplasm.