In a recently published study, Zhao et al. described a higher frequency of FLT3 mutations in ALL patients when evaluated by NGS (6.3% ITD and 18.8% TKD) and identified new non-canonical genetic variants, such as point mutations outside the TKD and insertion/deletion variants causing in-frame amino acid alterations. The gene discussed is FLT3; the disease is acute lymphoblastic leukemia.