The cut-off values in prognostic death prediction of ARDS patients by serum FOXM1 and IGF2 mRNA were 0.61 and 2.39, respectively, and the AUC in prognostic death prediction by serum FOXM1 mRNA combined with IGF2 mRNA was 0.902, which was superior to 0.789 and 0.812 (Z/P = 3.161/0.002, 3.278/0.001) in single detection, as shown in Table 7 and Figure 3. This evidence concerns the gene FOXM1 and acute respiratory distress syndrome.