Mean percentage and absolute changes, relative to pretreatment values, of serum urea nitrogen (SUN), creatinine, and symmetric dimethyl arginine (SDMA) concentrations 7 and 30 days after initiating treatment with the renin-angiotensin-aldosterone system inhibitors (RAASi) enalapril (E) or telmisartan (T) for 29 dogs with proteinuric chronic kidney disease (CKD). This evidence concerns the gene REN and chronic kidney disease.