APP and Alzheimer disease: Notably, the COWAS global test identified the pair comprised of amyloid-beta precursor protein (APP) and death-associated protein kinase 2 (DAPK2) as significant for AD (P=1.25e-05), while a standard PWAS analysis failed to identify either of these proteins (P=7.72e-04 for APP and P=1.31e-02 for DAPK2).