APOE and Alzheimer disease: Although the three pairs identified by the COWAS interaction test with EADB GWAS data either failed quality control or did not reach Bonferroni significance with IGAP GWAS data, the COWAS interaction test did identify 10 other proteins using IGAP GWAS data whose co-expression with APOE significantly affects AD risk, reinforcing the same molecular pathway implicated in our EADB-based analysis.