Furthermore, we prioritized several genes without strong literature evidence but predicted to be the most likely gene responsible underlying the PD GWAS signal with a probability greater than 80% by L2G or Yu2024 (SIPA1L2, SH3GL2, TMEM163, MAP4K4, LCORL, CAMK2D, STK39)20,21 (Fig. 1). The gene discussed is SH3GL2; the disease is Parkinson disease.