In addition to prioritizing known and well-established PD genes, including SNCA, LRRK2, GBA1, TMEM175 and VPS13C, we identified six genes (FYN, DYRK1A, NOD2, CTSB, SV2C, and ITPKB) emerged as promising targets for drug repurposing or novel therapeutic development. Here, DYRK1A is linked to Parkinson disease.