RNA sequencing results showed a synergistic induction of genes associated with RA signaling (RARB, RARG), neuronal differentiation (HOXC5, PBX1), and chromatin remodeling (RYBP, JADE2), which are positively correlated with favorable prognosis in neuroblastoma (Fig. 3C, S3C). The gene discussed is JADE2; the disease is neuroblastoma.