However, indolent lymphomas, such as follicular lymphoma (FL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL), can potentially evolve into a more aggressive form such as DLBCL detected through histologic transformation, often with acquisition of MYC and BCL2 and/or BCL6 rearrangements63. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.