An anti-inflammatory role of tryptophan in the heart is consistent with the negative z activation scores of “IL-13 activation pathway”, “cytokine storm signaling,” and “cardiac hypertrophy signaling,” (−0.447 −2.53 and − 2.71, respectively), signifying inhibition of these pathways by tryptophan supplementation. The gene discussed is IL13; the disease is cardiac hypertrophy.