We administered once weekly I.V. injections over 6 weeks of LNP-CTNNB1 starting at 5-weeks post-HDTVi, when microscopic tumor foci are established, at 3mg/kg, 1mg/kg, 0.3mg/kg, 0.1mg/kg, and 0.03mg/kg dosages (Figure S2a). This evidence concerns the gene CTNNB1 and neoplasm.