Given that our unbiased bioinformatic analysis identified other putative TFs, including POU2F1, whose function may be modulated in the context of β-catenin-mutated livers, we posit there exist an immune-regulatory module of TFs suppressed by mutated-β-catenin which modulates expression of key cytokines and chemokines involved in immune response, possibly in other tumor types as well. This evidence concerns the gene POU2F1 and neoplasm.