Given the role of T cells in promoting anti-tumor immunity, we examined expression of T cell marker genes Cd2, Cd3d, Cd3e, Cd3g, and Cd4 by cluster and treatment response group, which revealed enrichment of Cd3e, Cd3g, and Cd4 within β-M R animals in clusters 9 and 12 (Figure 7a), respectively, in which these tumor cell specific clusters decreased, compared to β-M Control and β-M NR animals (Figure 6h). The gene discussed is CD3D; the disease is neoplasm.