CTNNB1 and hepatocellular carcinoma: KEGG pathway analysis and gene set enrichment analysis on the reprogrammed hepatocytes demonstrated enrichment of pathways across all three liver lobule zones, including biosynthesis of cofactors (Zone 1), arginine biosynthesis (Zone 1), peroxisome (Zone 1), glutamate metabolism (Zone 3), glycolysis/TCA cycle (Zone 3), along with fatty acid metabolism, a pathway hallmark of CTNNB1-mutated hepatocellular cancers (Figure S9a–d).