However, with LNP-CTNNB1 treatment, tumor cells begin to express zone 1 markers, including Cyp2f2, Arg1, and Ass1 (Figure S12a–b), while decreasing expression of zone 3 genes (e.g., Cyp2e1, Cyp1a2, and Oat). This evidence concerns the gene CTNNB1 and neoplasm.