However, although patients with non‐BRAFV600E‐mutated LCH generally exhibited less severe disease, a subset of patients with specific mutations, such as BRAF exon 12 small duplications, BRAF exon 12 small deletions, MAP2K1F53C, MAP2K1Q56_G61delinsR, and MAP2K1F53_Q58delinsL, presented with life‐threatening conditions. The gene discussed is BRAF; the disease is Langerhans cell histiocytosis.