In the HIPP, protein content was not significantly different between groups when looking at total APP, sAPPα, sAPPβ, BACE1, the sAPPα/sAPPβ ratio, nor was BACE1 and ADAM10 enzyme activity affected by ovarian failure (P > 0.05; Figure 7A–E,G,I). Here, ADAM10 is linked to ovarian dysfunction.