Homozygous deletion of MTAP is frequently observed in cancers as it is an especially efficient mechanism for removing multiple tumor suppressor transcripts, including non‐small cell lung cancer (NSCLC), mesothelioma, pancreatic cancer, glioblastoma, head and neck cancer, esophageal cancer, bladder cancer, and malignant peripheral nerve sheath tumors (MPNST) [8, 27]. This evidence concerns the gene MTAP and head and neck cancer.