CAMK2G and myocardial infarction: The key ionic current remodelling underlying calcium-driven alternans include enhanced CaMKII activity and slower calcium release, as well as suppressed SERCA pump activity in the chronic MI, which are consistent with previous studies (Livshitz and Rudy, 2007; Zhou et al., 2016; Tomek et al., 2018; Appendix 1—figure 15).