Recently, due to advances in cryogenic electron microscopy (cryo‐EM) previously unidentified, cytoplasmic protein aggregates in the brains of a diverse range of neurodegenerative diseases including FTLD, DLB, progressive supranuclear palsy (PSP), and PD were discovered to contain homotypic fibrils of the CT fragment of TMEM106B localized to the cytosol.12, 13, 14, 15, 16. The gene discussed is TMEM106B; the disease is supranuclear palsy, progressive, 1.