Protein aggregation of tau, amyloid beta peptide, α‐synuclein, and TAR DNA binding protein 43 (TDP‐43) represent well‐characterized drivers of diverse proteinopathy disorders associated with dementia that include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD).5, 6, 7. This evidence concerns the gene APP and Alzheimer disease.