BRCA2 and neoplasm: Ferdinandos Skoulidis, at that time an MD, PhD student in my lab, working with Liam Cassidy, also then my PhD student, found that inactivation of a single copy of BRCA2 was sufficient to accelerate pancreatic carcinogenesis in our new model...but the tumours retained an intact second copy, which was still expressed normally, and remained resistant to PARP inhibitors.