For example, green tea catechin (–)-epigallocatechin gallate (EGCG) [221] and black tea metabolite theaflavin-3,3ʹ-digallate (TF3) [223] downregulate VEGF expression and inhibit tumor angiogenesis by suppressing the PI3K/AKT/mTOR/HIF1α signaling pathway. This evidence concerns the gene AKT1 and neoplasm.