Therefore, dysfunction of H3R signalling may plausibly affect the excitation-inhibition signalling balance observed in schizophrenia, the disruption of which has also been associated with working memory impairment (Gonzalez-Burgos et al. 2015; Hoftman et al. 2017, 2018; Calvin and Redish 2021). This evidence concerns the gene HRH3 and schizophrenia.