Interestingly, compared to other antipsychotics, clozapine has the highest affinity for H3R as an agonist (Kaar et al. 2020), and has been found to improve general cognition, including working memory, in patients with schizophrenia (Lee et al. 1994; McGurk 1999; Woodward et al. 2005). The gene discussed is HRH3; the disease is schizophrenia.