Additionally, H3R antagonists improve prepulse inhibition (PPI) deficits in rodents (Fox et al. 2005; Raddatz et al. 2012), which is a well-replicated feature of schizophrenia and is attributed to sensorimotor gating dysfunction (Graham 1975; Hoffman and Ison 1980; Kumari et al. 2000). This evidence concerns the gene HRH3 and schizophrenia.