HSPD1 and cancer: In fact, there is evidence that specific Hspd1 gene silencing [HSP60 inhibition] in cancer cells not only leads to reduced protein levels for the FAO-related short-chain enoyl-CoA hydratase 1 (ECHS1), hydroxy acyl-CoA (HADH) and middle-chain acyl-CoA dehydrogenase MCAD enzymes28–30, but also results in defective mitochondrial ATP-linked respiration31.