POM121 and amyotrophic lateral sclerosis: Recently, patient induced pluripotent stem cell (iPSC) derived neuron (iPSN) models of sALS and C9orf72 ALS/FTD have been utilized to detail an injury to the nuclear pore complex (NPC) that begins with the reduction of the transmembrane nucleoporin (Nup) POM121 as an early and significant contributor to disease [22, 23].