In fact, it has been demonstrated that the collective reduction of 8 Nups is sufficient to impact active nuclear import and the localization of mediators of nucleocytoplasmic transport (NCT), the localization and function of TDP-43, and neuronal survival in sALS and C9orf72 ALS/FTD iPSNs [22, 23]. Here, TARDBP is linked to amyotrophic lateral sclerosis.