CHMP7 and nasopharyngeal carcinoma: Given our prior demonstration that the nuclear accumulation of CHMP7 is sufficient to drive aberrant and pathologic reduction of specific Nups from the neuronal NPC [23], we hypothesized that the CHMP7/ESCRT-III nuclear surveillance pathway may be overactive in sALS thereby facilitating aberrant Nup molecule/protein turnover to give rise to this documented NPC injury.