With an IC50 in the low nanomolar range, lurbinectedin, ecubectedin and PM54 were far more cytotoxic than Pt + PMX in MPM cells and disabled the formation of tumor spheres independently from histological subtype or status of BAP1, whose deletion is a critical step in the malignant transformation of mesothelial cells [10]. Here, BAP1 is linked to neoplasm.