GPR183 and neoplasm: To test for EBI2 function in naive lymphocyte homing to peripheral sites, we employed the subcutaneous MC38 tumor model since it is a “hot” tumor with increased immune cell infiltration compared with other murine tumor lines.49 At 16 days post implantation, EBI2−/− and WT lymphocytes were transferred IV, and tumors were analyzed 90 min later to assess entry-specific effects (Figure 6D).