In our study, we found that ANGPTL3 overexpression suppressed SNAI1 mRNA expression, suggesting that SNAI1 is transcriptionally regulated by ANGPTL3. Clinical correlation analysis further indicated that ANGPTL3 is inversely correlated with SNAI1 expression, supporting the idea that SNAI1 is a target gene of ANGPTL3. The precise regulatory mechanisms between ANGPTL3 and SNAI1 in HCC warrant further investigation. Here, ANGPTL3 is linked to hepatocellular carcinoma.