Cytokine activation of bystander immune cells, such as monocytes and macrophages, secreting IL-6, Monocyte Chemotactic Protein-1 (MCP-1), and soluble CD40L is closely associated with inflammation or lymph node metastasis of head and neck cancer.9, 10, 11. The gene discussed is CCL2; the disease is metastatic malignant neoplasm in the lymph nodes.