AKT1 and Sepsis: In particular, the H2-T6SS, whose regulation is still not completely understood, has recently been linked to internalization into eukaryotic cells via a PI3K/Akt-dependent pathway.33,34 One of the H2-T6SS effectors is PldA, a phospholipase D associated with the killing of bacterial competitors and internalization into non-phagocytic cells.35 The pldA gene is not universally present in all P. aeruginosa isolates, and a recent study uncovered a high prevalence of pldA in P. aeruginosa isolates associated with severe acute pulmonary infection and septicemia.