ICV-STZ is reported to chronically diminish cerebral glucose uptake and develop insulin resistance in the brain, promoting pathological deposition of insoluble and neurotoxic Aβ1−42 and oxidative stress (Grieb, 2016), with the consequential hypersecretion of various cytokines including TGF-β−1 (Olajide and Sarker, 2020). Here, TGFB1 is linked to Insulin resistance.