By comparing people with MS with vs. without DSI [18], we found significantly decreased CSF synaptic markers levels in the first compared to the latter group (β-synuclein p = 0.044; SNAP-25 p = 0.025; neurogranin p = 0.007) (Fig. 4, Supplementary Table S4). Here, SNAP25 is linked to myeloid sarcoma.