Examples of these pathways include bladder cancer, endocrine resistance, GnRH signaling, estrogen signaling, ErbB signaling, colorectal cancer, PD-L1 and PD-1 checkpoints, IL-17 signaling, choline metabolism in cancer, breast cancer, TNF signaling, chemical carcinogenesis, and pathways in cancer (Figure 7A). The gene discussed is TNF; the disease is breast carcinoma.