ESR2 and cancer: The HUMAN PROTEIN ATLAS online tool was employed to study the expression of PTGS2/ESR2/EGFR/JUN/MMP2 genes’ signature components at protein levels in different types of human cancers, as seen in Figure 9A to D, immunohistochemistry analysis of 20 other human cancers showed variant protein expression levels of each component individually, with the highest protein level found in thyroid, colorectal, and carcinoid cancers.