PGR and cancer: In alignment with our findings, previous reports, using several in silico database analyses, have predicted the possible molecular mechanisms by which frankincense and myrrh, the main ingredients of the Xihuang pill, can inhibit hepatic cellular carcinomas57 and breast tumor growth, invasion, angiogenesis, and regulating cancer stemness capacity.18 Furthermore, our in silico TCMSP investigations showed that Guggulsterone (GUG) is one of the myrrh bioactive components that target breast cancer genes (i.e. PGR and PTGS2).