Platelets are known to influence glioma occurrence, and in this study, we identified nine platelet-related prognostic signature genes—CAPG, CLIC1, GLB1, GNG12, KIF20A, PDIA4, SULF2, TAGLN2, and WEE1. The IHC analysis showed that in addition to the expression of GNG12 and TAGLN2, the expression of CAPG, CLIC1, GLB1, KIF20A, PDIA4, SULF2, and WEE1 were all expressed in the glioma tissues than in the normal tissues (low or high). This evidence concerns the gene TAGLN2 and central nervous system cancer.